2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10433
    Xanthine oxidase-IN-9 2571069-61-7 98%
    Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM.
    Xanthine oxidase-IN-9
  • HY-N10434
    Anti-inflammatory agent 28 98%
    Anti-inflammatory agent 28 (Compound 9) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 28
  • HY-N10435
    Anti-inflammatory agent 29 98%
    Anti-inflammatory agent 29 (Compound 7) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 29
  • HY-N10436
    Anti-inflammatory agent 30 2573174-21-5 98%
    Anti-inflammatory agent 30 (Compound 5) is an anti-inflammatory agent with hepatoprotective activity.
    Anti-inflammatory agent 30
  • HY-N10594
    Cirsiliol 4′-glucoside 41087-98-3 98%
    Cirsiliol 4′-glucoside is a free radical scavenger, found from Ruellia tuberosa L. Cirsiliol 4′-glucoside shows potential anti-diabetic activity.
    Cirsiliol 4′-glucoside
  • HY-N10597
    5'''-O-Feruloyl complanatoside B 142473-98-1 98%
    5'''-O-Feruloyl complanatoside B is isolated from Astragali Semen, the seeds of Astragalus Complanatus. Semen Astragali Complanati (SAC) include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements; have been reported to involve in chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers.
    5'''-O-Feruloyl complanatoside B
  • HY-N10606
    Uvagrandol 98%
    Uvagrandol potently inhibits α-glucosidase and porcine lipase (IC50: 15.2 μM, 11.2 μM respectively). Uvagrandol can be used in the research of Type 2 diabetes and obesity.
    Uvagrandol
  • HY-N10618
    Epilactose 50468-56-9 99.89%
    Epilactose is a disaccharide composed of galactose and mannose with prebiotic properties. Epilactose significantly stimulates the butyrate-producing bacteria, increasing the butyrate production and holds potential functional properties for human health.
    Epilactose
  • HY-N10648
    PTP1B-IN-20 3001295-81-1 98%
    PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition.
    PTP1B-IN-20
  • HY-N10669
    Apigenin 4′-O-β-D-glucopyranoside 20486-34-4 98%
    Apigenin 4′-O-β-D-glucopyranoside is a flavonoid that can be found in caledonian guioa villosa.
    Apigenin 4′-O-β-D-glucopyranoside
  • HY-N10755
    (+)-ε-Viniferin 129170-22-5 98%
    (+)-ε-Viniferin is a stilbenes compound with PGE2 inhibition effect, and is an orally active anti-inflammatory agent. ε-viniferin is also able to reduce fat accumulation, thus can be used for research of inflammation or obesity.
    (+)-ε-Viniferin
  • HY-N10761
    Itaconoyl-CoA 6008-93-1 98%
    Itaconoyl-CoA (Itaconoyl coenzyme A) is a coenzyme A derivative.
    Itaconoyl-CoA
  • HY-N10770
    5'-Geranyl-5,7,2',4'-tetrahydroxyflavone 1221762-70-4 98%
    5'-Geranyl-5,7,2',4'-tetrahydroxyflavone, a phenolic compound, presents strong oxygen radical absorbance capacity (ORAC), DPPH radical-scavenging capacity, ABTS radical-scavenging capacity, ferric reducing antioxidant power (FRAP) and nitrite-scavenging capacity. 5'-Geranyl-5,7,2',4'-tetrahydroxyflavone has the potential for natural antioxidant research.
    5'-Geranyl-5,7,2',4'-tetrahydroxyflavone
  • HY-N11086
    Tris(dihydrocaffeoyl)spermidine 859341-34-7 98%
    Tris(dihydrocaffeoyl)spermidine is an active compound. Tris(dihydrocaffeoyl)spermidine can be isolated from potato (Solanum tuberosum) tubers. Tris(dihydrocaffeoyl)spermidine can be used for the research of metabolism.
    Tris(dihydrocaffeoyl)spermidine
  • HY-N11089
    23,24-Dihydroisocucurbitacin D 3877-89-2 98%
    23,24-Dihydroisocucurbitacin D (compound 22) is a cucurbitacin.
    23,24-Dihydroisocucurbitacin D
  • HY-N11142
    Gb3(18:1/18:0) 69283-33-6 98%
    Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product.
    Gb3(18:1/18:0)
  • HY-N11448
    Bupleuroside XIII 197705-31-0 98%
    Bupleuroside XIII is a natural hepatoprotective saponin.
    Bupleuroside XIII
  • HY-N11454
    Lacto-N-neodifucohexaose II 2583908-45-4 98%
    Lacto-N-neodifucohexaose II (Compd 9) is a derivative of key human milk tetrasaccharide. Lacto-N-neodifucohexaose II is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Lacto-N-neodifucohexaose II
  • HY-N11455
    Lacto-N-difucohexaose I 16789-38-1 98%
    Lacto-N-difucohexaose I (LNDFH I), a linker, could be used to combine oligosaccharides containing Lewis b sugar chain to water insoluble polysaccharide.
    Lacto-N-difucohexaose I
  • HY-N11477
    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid 132282-70-3 98%
    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid is a saponin that can be isolated from Rubus ellipticus var. obcordatus. (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid inhibits α-Glucosidase with an IC50 of 1.68 mM.
    (2α,3β,4α)-2,3,19-Trihydroxyurs-12-ene-23,28-dioic acid
Cat. No. Product Name / Synonyms Application Reactivity